Ranked by data
The best fat-loss peptides — GLP-1s, GIP agonists, and metabolic compounds — ranked by fat-loss effectiveness scores, with dosing and sourcing.
10 compounds · ranked by fat loss score
The metabolic-peptide class spans GLP-1/GIP/glucagon agonists through mitochondrial compounds like 5-Amino-1MQ. This ranking sorts them by our 0–10 fat-loss effectiveness score so the strongest recomposition agents surface first. Check each guide for titration schedules and side-effect management before drawing conclusions.
Amylin Analog + GLP-1 Receptor Agonist (Fixed-Ratio Combo)
Evidence-based CagriSema guide: cagrilintide + semaglutide titration, weekly dosing, recomp and cruise protocols, side-effect management, and stack options.
Read the full CagriSema guideGLP-1 / GIP / Glucagon Triple Agonist
Evidence-based retatrutide guide: weekly dosing and titration, physique-focused cutting and recomp protocols, TRT stack for muscle retention, side effects.
Read the full Retatrutide guideAvailable at Real Peptides (US) — 20% off auto-applied
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Dual GIP/GLP-1 Receptor Agonist
Tirzepatide guide for physique-focused users: microdose and cutting protocols, muscle-preservation strategy, titration schedule, stacking with test and T3, and GI side-effect management.
Read the full Tirzepatide guideAvailable at Real Peptides (US) — 20% off auto-applied
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GLP-1/Glucagon Dual Receptor Agonist
Evidence-based mazdutide guide for recomp and aggressive cuts: GLORY-1 titration to 4–6 mg weekly, stack options, side-effect management, and MASLD-focused protocol.
Read the full Mazdutide guideAvailable at Real Peptides (US) — 20% off auto-applied
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GLP-1 Receptor Agonist
Evidence-based semaglutide guide for physique users: SC dosing and titration, microdose recomp, on-cycle appetite control, GH/slin stacking, and muscle-sparing protocol.
Read the full Semaglutide guideGLP-1/Glucagon Dual Receptor Agonist
Survodutide (BI 456906) guide: GLP-1/glucagon dual agonist titration, weekly dosing, liver-fat and recomp protocols, side effects, and how it compares to tirzepatide.
Read the full Survodutide guideAvailable at Real Peptides (US) — 20% off auto-applied
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Triple Monoamine Reuptake Inhibitor (SNDRI)
Evidence-based tesofensine guide: 500mcg cutting protocol, GLP-1 plateau stack, cardiovascular monitoring, 9-day half-life, side effects and contraindications.
Read the full Tesofensine guideAvailable at Real Peptides (US) — 20% off auto-applied
A 10-week protocol at 375 mcg/day ≈ 1 bottle
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Long-Acting Amylin Analog (DACRA)
Evidence-based cagrilintide guide: weekly SC dosing, titration schedule, CagriSema stack with semaglutide, side effects, and protocols for cuts and appetite control.
Read the full Cagrilintide guideAvailable at Real Peptides (US) — 20% off auto-applied
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Thyroid Hormone (T3)
T3 protocol for bodybuilders and looksmaxxers: ramp/taper dosing, pre-contest stacks with tren and clen, GH-induced low-T3 replacement, and muscle-sparing strategy.
Read the full Liothyronine guideAvailable at Swiss Chems (US) — 10% off auto-applied
A 6-week protocol at 37.5 mcg/day ≈ 1 bottle
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Proapoptotic Homing Peptidomimetic
Evidence-based Adipotide (FTPP) guide: dosing protocol from the Barnhart primate data, visceral fat targeting, GLP-1 stack placement, and the renal monitoring that keeps it safe.
Read the full Adipotide guideAvailable at Swiss Chems (US) — 10% off auto-applied
A 3-week protocol at 0.35 mg/day ≈ 2 vials
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Every compound in our library is scored 0–10 on six effectiveness axes (muscle growth, fat loss, strength, endurance, recovery, cognition) as part of our content pipeline. This page filters the library to Metabolic Peptide and sorts by the fat loss score. Compounds that score zero on this axis are omitted. Rankings recompute automatically whenever the underlying compound data changes — they are never influenced by affiliate relationships.