Recovery Stacks

The mid-tier SARM physique cycle — RAD-140 drives mass and aggression, LGD-4033 adds density and strength, MK-677 supports recovery, sleep, and connective tissue, with on-cycle enclomiphene to maintain HPTA function and TUDCA for liver protection throughout. Full PCT with both SERMs to fully restart.

Full hierarchical restart of a crashed hypothalamic-pituitary-testicular axis — kisspeptin signals upstream at the hypothalamus, gonadorelin pulses GnRH at the pituitary, and enclomiphene blocks negative feedback at the hypothalamus while preserving estrogen signalling. Covers the entire axis top-down.

Four non-overlapping mechanisms for deeper, more restorative sleep — magnesium L-threonate crosses the blood-brain barrier and modulates NMDA, glycine activates inhibitory glycinergic pathways, apigenin acts on adenosine and GABA, and low-dose melatonin signals circadian timing without next-day grogginess. No mechanism redundancy.

Peter Attia's ApoB-driven cardiometabolic stack — rosuvastatin lowers LDL particle count, ezetimibe blocks cholesterol absorption (synergistic with statin), telmisartan controls blood pressure with PPARγ benefits, and empagliflozin lowers cardiovascular events independent of diabetes. The most evidence-backed cardiovascular longevity protocol.

David Sinclair's foundational longevity protocol — NMN restores NAD+ (the substrate for sirtuin and PARP function), resveratrol activates SIRT1, and spermidine drives autophagy independently. Each compound hits a distinct longevity lever — no NMN/NR double-up, no AMPK redundancy.

The Attia/ITP-data-backed longevity duo — weekly rapamycin pulses inhibit mTOR (the most consistently life-extending intervention in mammals), while daily metformin activates AMPK and improves glucose handling. Two distinct anti-aging pathways with complementary mechanisms and decades of human data.

The actual published Mayo Clinic senolytic protocol — dasatinib + quercetin pulsed for 2-3 consecutive days, repeated quarterly. Selectively clears senescent ('zombie') cells that drive age-related dysfunction and inflammation. Brief intermittent dosing avoids the chronic exposure problems of daily anti-aging drugs.

Connor Murphy & Tony Huge's framework for pushing beyond natural limits without traditional anabolic steroids — uses low-suppression SARMs, GH secretagogues, healing peptides and test-optimization to maximise lean mass while preserving HPTA function and long-term health.

Three-layer mitochondrial overhaul with no mechanism overlap — urolithin A induces mitophagy (clears damaged mitochondria), MOTS-c is a mitochondrial-derived peptide that boosts metabolic flexibility and AMPK signalling, and 5-Amino-1MQ inhibits NNMT to restore NAD+ and drive lipolysis. The cleanest non-pharmaceutical mitochondrial protocol.

The cleanest GH-amplification protocol available — CJC-1295 (no DAC / Mod GRF 1-29) provides the GHRH pulse, while ipamorelin acts as a selective ghrelin mimetic without raising cortisol or prolactin. Mimics natural GH pulsatility for recovery, sleep, body composition, and skin quality.

The classic peptide healing pair — BPC-157 drives angiogenesis, gut repair, and tendon-ligament regrowth, while TB-500 mobilizes stem cells and accelerates soft-tissue migration. Together they cover the full healing cascade from acute injury through chronic tissue remodeling.