GH Pulse Pair (CJC-1295 + Ipamorelin)

Risk: Low

The cleanest GH-amplification protocol available — CJC-1295 (no DAC / Mod GRF 1-29) provides the GHRH pulse, while ipamorelin acts as a selective ghrelin mimetic without raising cortisol or prolactin. Mimics natural GH pulsatility for recovery, sleep, body composition, and skin quality.

RecoveryAesthetics
12-week cycle2 compounds
Best forRecovery 7/10
Cycle12wk
Compounds2
RiskLow
4 min read

Composition: 2 GH & IGF Axis

1× 3× daily1× Custom

Overview

The GH Pulse Pair (CJC-1295 + Ipamorelin) stack is the most widely used peptide combo for anyone chasing GH-driven recovery, slow-burn fat loss, better sleep, better skin, and joint support—without the water retention or suppression risks of exogenous HGH. By stacking CJC-1295 (no DAC) and ipamorelin, you leverage both GHRH and GHRP pathways to trigger your own natural GH pulses. This is not a mass-builder protocol—think enhanced healing, smoother skin, and a real (if slow) shift in body composition over 12 weeks. No PCT needed, and equally effective for men and women focused on aesthetics, recovery, or healthy aging.

Why this stack works

CJC-1295 (no DAC) acts as a GHRH analog, priming the pituitary for a GH release, while ipamorelin (a next-gen GHRP) provides the trigger signal to actually release the stored GH. When dosed together, they synergize: CJC sets the stage, ipamorelin pulls the lever. Pulsatile (2–3x daily) subq dosing maintains physiologic surges, supporting IGF-1 without flattening your natural rhythm or cranking up undesired hormones like cortisol or prolactin. This dual-peptide approach is trusted for visible skin and sleep improvements within weeks and subclinical bodyfat and recovery shifts by the end of the cycle.

Protocol timeline

1 phase · 12 weeks total

Timeline shows the 12-week cycle. Bars overlap when phases run concurrently. Click a bar to jump to its detail card.

Cycle starts

2025

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2026

Jan

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2027

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Phase 1
GH Pulse Cycle
mainWk 1–1212wk
CJC-1295Ipamorelin
WeekCompoundDoseFrequencyNotes
1–12CJC-1295100 mcg2–3x daily, SubQAlways paired 1:1 with ipamorelin
1–12Ipamorelin100 mcg2–3x daily, SubQAdminister together, same syringe

How to run it:

  • Dose CJC-1295 (no DAC) and ipamorelin together, 100 mcg each in the same SubQ shot, 2 or 3 times daily.
  • Optimal timing: on an empty stomach AM (immediately upon waking), pre-workout (if training), and/or pre-bed. Space doses at least 4 hours apart.
  • Avoid food 30 minutes before and after injections (especially carbs/fats) to maximize GH pulse.
  • Use fine insulin syringes (29–31g) for shallow SubQ injection—abdomen or thigh.
  • 12 weeks is the standard cycle before a break; no PCT required.
  • If you have a history of insulin resistance or are running a calorie surplus, monitor for mild blood glucose drift over the cycle (ipamorelin/CJC effect). Intervene with berberine or metformin if fasting glucose trends up.
  • Expect mild water retention (subq, not severe). If it becomes problematic, drop frequency to 2x/day.
  • Pair this phase with a collagen/glycine/vitamin C supplement (once daily) if skin or tendon quality is a primary goal.
  • For nighttime dosing: if you notice elevated nocturnal cortisol or sleep disturbance, switch the last dose to just pre-bed and skip the mid-day pulse.
  • Standard 100mcg/shot is well-tolerated and matches community practice. Double-check peptide reconstitution and storage protocols for stability.

Compounds in this stack

2 linked · tap for full guide

Ipamorelin

Growth Hormone Secretagogue (GHRP)

GH & IGFt½ ~2 hoursSubQResearch

CJC-1295

Long-Acting GHRH Analog

GH & IGFt½ 5.8–8.1 days (with DAC); ~30 min (no DAC / Mod GRF 1-29)SubQResearch

How they work together

Combined effectiveness
Average 0–10 score per dimension across the compounds in this stack (simple mean per axis).
Pairwise synergies

Multipliers applied to the projection above when these compounds run together. Values > 1 indicate a bonus, < 1 a penalty.

PairTypeLeanFat lossRecovery
CJC-1295+Ipamorelin
synergistic×1.18×1.22×1.28

Cycle outcome projection

Projection across all phases (12 weeks total) using the same math as the stack-calculator tool. Adjust gender, cycle length, and goal to see how the numbers move.

Projected Outcomes
Male · 12-week cycle · Ipamorelin + CJC-1295
12wk

Body Transformation Preview

Average
Very LeanAverageHigh BF
Fit
UntrainedAthleticEnhanced
Before: Fit, Average body fat
BeforeFit · Average BF
After Cycle: Fit, Lean body fat
After CycleFit · Lean BF
+2.9 lb muscle−4.9 lb fatover 12 weeks

Lean Mass Gain

2.9 lbs

2.2–3.7 lbs range

Fat Loss

4.9 lbs

3.6–6.1 lbs range

Lean Synergy Bonus

+18%

from compound pairing

Fat Loss Synergy

+22%

from compound pairing

Per-Compound Contribution

Ipamorelin+0.10 lb lean/wk · −0.20 lb fat/wk
CJC-1295+0.15 lb lean/wk · −0.20 lb fat/wk

Fat Loss by Week

Wk 1
0.49 lb
Wk 2
0.47 lb
Wk 3
0.45 lb
Wk 4
0.44 lb
Wk 5
0.42 lb
Wk 6
0.41 lb
Wk 7
0.39 lb
Wk 8
0.38 lb
Wk 9
0.37 lb
Wk 10
0.35 lb
Wk 11
0.34 lb
Wk 12
0.33 lb

Where to buy

Swiss Chems

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Conclusion

If you want all the downstream perks of higher GH—better sleep, connective tissue resilience, skin glow—without the cost and side-effect baggage of HGH, this protocol is as good as it gets. Next step: lock in your peptides, dial in your timing, and get baseline labs (IGF-1 is the marker).

Project cycle outcomesOpen in stack builder← All stacks

Updated 2026-04-19