Natty Plus Protocol
Risk: ModerateConnor Murphy & Tony Huge's framework for pushing beyond natural limits without traditional anabolic steroids — uses low-suppression SARMs, GH secretagogues, healing peptides and test-optimization to maximise lean mass while preserving HPTA function and long-term health.
Composition: 7 Supplements · 2 Healing Peptides · 1 Ancillary / PCT · 1 SARM · 1 Metabolic Peptide · 1 GH & IGF
Overview
The Natty Plus Protocol is the blueprint for anyone serious about pushing past 'natural' limits without committing to traditional anabolic steroids. Built for the modern body-recomp or looksmaxxing crowd, this protocol leverages the best-over-the-counter (and gray-market) tools: low-suppression SARMs (AC-262), a dialed-in GH axis via MK-677, world-class recovery peptides, and proven testosterone optimizers. You get real increases in lean mass, strength, and recovery, all while keeping your HPTA live and preserving fertility. If you've already run 'natty' stacks to diminishing returns but want more flex and faster gains without the risks and PCT headaches of harsh AAS, this is your move. The stack is mapped for 16 weeks, blending 1-2 anabolic windows with regenerative deloads, ending with a true HPTA kick to make sure your baseline is healthier than when you started. Not a "health food store" run — it's as close as you can get to black-market results with white-market safety.
Why this stack works
- Foundation Phase: Creatine covers strength and fullness, ashwagandha & tongkat+fadogia modulate both cortisol and test, TUDCA+NAC for baseline liver resilience, and berberine keeps lipids and glucose in check — crucial for any protocol with GH or peptides.
- GH Axis (MK-677): Driving 24/7 GH and IGF-1 output via oral MK-677 leverages healing, sleep, and mild anabolic synergy with SARMs for faster recomposition and skin/collagen effects. Insulin sensitivity support (berberine) is intentionally stacked here.
- Anabolic Blocks (AC-262): AC-262 is the low-suppression SARM that gives you a real bump in lean mass without nuking endogenous testosterone or risking a serious shutdown. Two 4-week runs, split by a recovery window, maximize progress with minimal suppression.
- Recovery Window (BPC-157/TB-500): These peptides address the tissue repair angle that heavy training and even mild SARMs cycles can stall. Their stacking builds synergy: BPC for local healing, TB-500 for global recovery. Drop the SARM during this phase to let the axis breathe.
- Body Composition (Retatrutide): Optional but powerful — GLP-1/GIP/glucagon triple-agonist that cuts appetite and upregulates fat oxidation, holding onto muscle when dieting alongside anabolics and GH secretagogues. Berberine doubles up metabolic protection here.
- Test Optimization / Mini-PCT: Enclomiphene at the tail end pops LH and FSH up fast, so your HPTA overshoots cleanly. Natural test boosters continue for cortisol balance and libido. Absolute gold if you want to bank your gains and keep sperm/axis intact.
Protocol timeline
7 phases · 16 weeks total
Timeline shows the 16-week cycle. Bars overlap when phases run concurrently. Click a bar to jump to its detail card.
Cycle starts
2025
Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
2026
Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
2027
Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 1–16 | Creatine | 5–10 g | Once daily | Mix in water, can split if needed |
| 1–16 | Ashwagandha (KSM-66) | 600 mg | Once daily | Take with food, morning or night |
| 1–16 | Tongkat Ali | 400 mg | Once daily | Standardized extract (eurycomanone) |
| 1–16 | Fadogia Agrestis | 600 mg | Once daily | 8 weeks on, 2 weeks off (see notes) |
| 1–16 | TUDCA | 500 mg | Once daily | Split into two doses if GI issues |
| 1–16 | NAC | 600 mg | Once daily | Run separately from orals |
| 1–16 | Berberine | 500 mg | 3x daily | With meals, spaced AM/noon/PM |
- Cycle Fadogia 8 weeks on, 2 weeks off to minimize rare toxicity risk.
- NAC can blunt absorption of some orals: space dosing by 2+ hours from any other supplements/meds.
- Berberine should always be taken with food due to GI side effects.
- Double-check any cross-supplement interactions if stacking multiple liver/antioxidant agents.
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 1–12 | MK-677 | 25 mg | Once daily | Evening dosing recommended for best sleep/GH pulse |
- MK-677 increases appetite, water retention, and may impair insulin sensitivity; monitor fasting glucose monthly.
- Pairing with berberine (from Foundation) helps mitigate insulin resistance.
- Appetite spike is real — prep your meal plan or macro targets to avoid accidental bulking.
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 1–4 | AC-262 | 20 mg | Once daily | Take AM or split AM/PM if desired |
- This phase overlays with both Foundation and GH Axis; take all compounds as scheduled.
- AC-262 has low suppression but check for any androgen or hair-related side effects.
- Do not exceed 20 mg unless experienced and monitoring bloodwork; 4 weeks at this dose is goldilocks for progression without harsh suppression.
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 1–12 | Retatrutide | 2–4 mg | Once weekly | Start at 2mg, titrate up to 4mg as tolerated |
| 1–12 | Berberine | 500 mg | 3x daily | Stacked for glucose/lipid management |
- Titrate Retatrutide slowly (initial 2 mg for 2 weeks, then progress to 4 mg if no GI issues).
- Maintain at least 1.6 g/kg lean mass protein to hard-lock against muscle loss in deficit.
- Watch for constipation/dehydration (common with GLP-1s); maintain robust hydration and salt.
- Avoid alcohol on injection days due to amplified nausea risk.
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 5–8 | BPC-157 | 500 mcg | Daily (AM) | SubQ or oral; site inject for injury |
| 5–8 | TB-500 | 2 mg | 2x/week (e.g. Mon/Thu) | SubQ, systemic; maintain rotation site |
- Healing peptides can mask pain — continue to reign in load/progressive overload if rehabbing injury.
- Adequate intake of glycine and zinc is substrate supportive for repair.
- Avoid anti-inflammatories (NSAIDs) during this period for maximal healing effect.
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 9–12 | AC-262 | 20 mg | Once daily | Resume immediately after Recovery |
| 9–12 | MK-677 | 25 mg | Once daily | Continue as per GH Axis phase |
- This SARM block stacks with GH/IGF axis (MK-677 ongoing) for maximal lean-mass accrual.
- Continue Foundation (liver, metabolic, test support) throughout.
- Recheck baseline labs at the end of week 12.
| Week(s) | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 13–16 | Enclomiphene | 12.5 mg | Once daily | Take in AM with food |
| 13–16 | Tongkat Ali | 400 mg | Once daily | Continue (Foundation ongoing) |
| 13–16 | Ashwagandha | 600 mg | Once daily | Continue (Foundation ongoing) |
| 13–16 | NAC | 600 mg | Once daily | Continue (Foundation ongoing) |
- Avoid SSRIs, MAOIs, or CYP2D6 inhibitors during this SERM window (risk of PK interactions).
- Be alert for vision disturbances (rare, but known SERM risk).
- Abstain from heavy alcohol and check hormone & liver panels 2–4 weeks after finishing Mini-PCT.
Compounds in this stack
13 linked · tap for full guide
Berberine
AMPK Activator / Isoquinoline Alkaloid
N-Acetylcysteine
Glutathione Precursor / Antioxidant
TUDCA
Hepatoprotective Bile Acid
Fadogia Agrestis
Natural Testosterone Support Herb
Tongkat Ali
Steroidogenic Botanical
Ashwagandha
Adaptogen / HPA-axis Modulator
Creatine Monohydrate
Ergogenic Amino Acid Derivative
Enclomiphene Citrate
SERM (HPTA Stimulator)
AC-262536
Partial Agonist SARM
Retatrutide
GLP-1 / GIP / Glucagon Triple Agonist
MK-677
Growth Hormone Secretagogue (GHS-R1a Agonist)
TB-500
Actin-Sequestering Peptide
BPC-157
Cytoprotective Peptide
How they work together
Multipliers applied to the projection above when these compounds run together. Values > 1 indicate a bonus, < 1 a penalty.
| Pair | Type | Lean | Fat loss | Recovery |
|---|---|---|---|---|
| additive | ×1.04 | ×1.00 | ×1.05 | |
| synergistic | ×1.12 | ×1.00 | ×1.22 | |
| synergistic | ×1.10 | ×1.08 | ×1.22 | |
| synergistic | ×1.00 | ×1.00 | ×1.18 | |
| synergistic | ×1.08 | ×1.00 | ×1.25 | |
| synergistic | ×1.13 | ×1.09 | ×1.07 | |
| synergistic | ×1.15 | ×1.05 | ×1.18 | |
| synergistic | ×1.12 | ×1.10 | ×1.20 | |
| synergistic | ×1.15 | ×1.05 | ×1.12 | |
| additive | ×1.00 | ×1.07 | ×1.00 | |
| synergistic | ×1.12 | ×1.08 | ×1.18 | |
| synergistic | ×1.13 | ×1.02 | ×1.22 | |
| synergistic | ×1.17 | ×1.04 | ×1.18 | |
| synergistic | ×1.14 | ×1.08 | ×1.28 | |
| synergistic | ×1.08 | ×1.00 | ×1.12 |
Cycle outcome projection
Projection across all phases (16 weeks total) using the same math as the stack-calculator tool. Adjust gender, cycle length, and goal to see how the numbers move.
Body Transformation Preview


Lean Mass Gain
65.8 lbs
49.4–82.3 lbs range
Fat Loss
31.9 lbs
23.9–39.9 lbs range
Lean Synergy Bonus
+322%
from compound pairing
Fat Loss Synergy
+89%
from compound pairing
Per-Compound Contribution
Fat Loss by Week
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Conclusion
This is the most complete, natty-plus protocol for anyone chasing maximum recomp and aesthetics without crossing the SARM/AAS suppression line. You retain your HPTA, add muscle, accelerate fat loss and recovery, and end with a platform for either cruising or launching a more aggressive cycle. Treat this as both a destination and a perfect launchpad for bigger moves. Once you've finished, reassess, run a full blood panel, and move upward or maintain as your goals dictate.
Updated 2026-04-19