Natty Plus Protocol

Risk: Moderate

Connor Murphy & Tony Huge's framework for pushing beyond natural limits without traditional anabolic steroids — uses low-suppression SARMs, GH secretagogues, healing peptides and test-optimization to maximise lean mass while preserving HPTA function and long-term health.

RecoveryAestheticsMuscle Gain
16-week cycle7 phases13 compoundsIncludes PCT phase
Best forFat Loss 10/10
Cycle16wk
Compounds13
RiskModerate
9 min read

Composition: 7 Supplements · 2 Healing Peptides · 1 Ancillary / PCT · 1 SARM · 1 Metabolic Peptide · 1 GH & IGF

1× 3× daily3× Twice daily7× Once daily1× Twice weekly1× Weekly

Overview

The Natty Plus Protocol is the blueprint for anyone serious about pushing past 'natural' limits without committing to traditional anabolic steroids. Built for the modern body-recomp or looksmaxxing crowd, this protocol leverages the best-over-the-counter (and gray-market) tools: low-suppression SARMs (AC-262), a dialed-in GH axis via MK-677, world-class recovery peptides, and proven testosterone optimizers. You get real increases in lean mass, strength, and recovery, all while keeping your HPTA live and preserving fertility. If you've already run 'natty' stacks to diminishing returns but want more flex and faster gains without the risks and PCT headaches of harsh AAS, this is your move. The stack is mapped for 16 weeks, blending 1-2 anabolic windows with regenerative deloads, ending with a true HPTA kick to make sure your baseline is healthier than when you started. Not a "health food store" run — it's as close as you can get to black-market results with white-market safety.

Why this stack works

  • Foundation Phase: Creatine covers strength and fullness, ashwagandha & tongkat+fadogia modulate both cortisol and test, TUDCA+NAC for baseline liver resilience, and berberine keeps lipids and glucose in check — crucial for any protocol with GH or peptides.
  • GH Axis (MK-677): Driving 24/7 GH and IGF-1 output via oral MK-677 leverages healing, sleep, and mild anabolic synergy with SARMs for faster recomposition and skin/collagen effects. Insulin sensitivity support (berberine) is intentionally stacked here.
  • Anabolic Blocks (AC-262): AC-262 is the low-suppression SARM that gives you a real bump in lean mass without nuking endogenous testosterone or risking a serious shutdown. Two 4-week runs, split by a recovery window, maximize progress with minimal suppression.
  • Recovery Window (BPC-157/TB-500): These peptides address the tissue repair angle that heavy training and even mild SARMs cycles can stall. Their stacking builds synergy: BPC for local healing, TB-500 for global recovery. Drop the SARM during this phase to let the axis breathe.
  • Body Composition (Retatrutide): Optional but powerful — GLP-1/GIP/glucagon triple-agonist that cuts appetite and upregulates fat oxidation, holding onto muscle when dieting alongside anabolics and GH secretagogues. Berberine doubles up metabolic protection here.
  • Test Optimization / Mini-PCT: Enclomiphene at the tail end pops LH and FSH up fast, so your HPTA overshoots cleanly. Natural test boosters continue for cortisol balance and libido. Absolute gold if you want to bank your gains and keep sperm/axis intact.

Protocol timeline

7 phases · 16 weeks total

Timeline shows the 16-week cycle. Bars overlap when phases run concurrently. Click a bar to jump to its detail card.

Cycle starts

2025

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

2026

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

2027

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Phase 1
Foundation (Always-On)
mainWk 1–1616wk
Creatine MonohydrateAshwagandhaTongkat AliFadogia AgrestisTUDCAN-AcetylcysteineBerberine
Week(s)CompoundDoseFrequencyNotes
1–16Creatine5–10 gOnce dailyMix in water, can split if needed
1–16Ashwagandha (KSM-66)600 mgOnce dailyTake with food, morning or night
1–16Tongkat Ali400 mgOnce dailyStandardized extract (eurycomanone)
1–16Fadogia Agrestis600 mgOnce daily8 weeks on, 2 weeks off (see notes)
1–16TUDCA500 mgOnce dailySplit into two doses if GI issues
1–16NAC600 mgOnce dailyRun separately from orals
1–16Berberine500 mg3x dailyWith meals, spaced AM/noon/PM
  • Cycle Fadogia 8 weeks on, 2 weeks off to minimize rare toxicity risk.
  • NAC can blunt absorption of some orals: space dosing by 2+ hours from any other supplements/meds.
  • Berberine should always be taken with food due to GI side effects.
  • Double-check any cross-supplement interactions if stacking multiple liver/antioxidant agents.
Phase 2
GH Axis (Continuous)
mainWk 1–1212wk
MK-677
Week(s)CompoundDoseFrequencyNotes
1–12MK-67725 mgOnce dailyEvening dosing recommended for best sleep/GH pulse
  • MK-677 increases appetite, water retention, and may impair insulin sensitivity; monitor fasting glucose monthly.
  • Pairing with berberine (from Foundation) helps mitigate insulin resistance.
  • Appetite spike is real — prep your meal plan or macro targets to avoid accidental bulking.
Phase 3
Anabolic Block 1 (AC-262)
mainWk 1–44wk
AC-262536
Week(s)CompoundDoseFrequencyNotes
1–4AC-26220 mgOnce dailyTake AM or split AM/PM if desired
  • This phase overlays with both Foundation and GH Axis; take all compounds as scheduled.
  • AC-262 has low suppression but check for any androgen or hair-related side effects.
  • Do not exceed 20 mg unless experienced and monitoring bloodwork; 4 weeks at this dose is goldilocks for progression without harsh suppression.
Phase 4
Body Composition (Optional Cut)
supportWk 1–1212wk
Retatrutide
Week(s)CompoundDoseFrequencyNotes
1–12Retatrutide2–4 mgOnce weeklyStart at 2mg, titrate up to 4mg as tolerated
1–12Berberine500 mg3x dailyStacked for glucose/lipid management
  • Titrate Retatrutide slowly (initial 2 mg for 2 weeks, then progress to 4 mg if no GI issues).
  • Maintain at least 1.6 g/kg lean mass protein to hard-lock against muscle loss in deficit.
  • Watch for constipation/dehydration (common with GLP-1s); maintain robust hydration and salt.
  • Avoid alcohol on injection days due to amplified nausea risk.
Phase 5
Recovery Window
supportWk 5–84wk
BPC-157TB-500
Week(s)CompoundDoseFrequencyNotes
5–8BPC-157500 mcgDaily (AM)SubQ or oral; site inject for injury
5–8TB-5002 mg2x/week (e.g. Mon/Thu)SubQ, systemic; maintain rotation site
  • Healing peptides can mask pain — continue to reign in load/progressive overload if rehabbing injury.
  • Adequate intake of glycine and zinc is substrate supportive for repair.
  • Avoid anti-inflammatories (NSAIDs) during this period for maximal healing effect.
Phase 6
Anabolic Block 2 (AC-262)
mainWk 9–124wk
AC-262536
Week(s)CompoundDoseFrequencyNotes
9–12AC-26220 mgOnce dailyResume immediately after Recovery
9–12MK-67725 mgOnce dailyContinue as per GH Axis phase
  • This SARM block stacks with GH/IGF axis (MK-677 ongoing) for maximal lean-mass accrual.
  • Continue Foundation (liver, metabolic, test support) throughout.
  • Recheck baseline labs at the end of week 12.
Phase 7
Test Optimization / Mini-PCT
pctWk 13–164wk
Enclomiphene Citrate
Week(s)CompoundDoseFrequencyNotes
13–16Enclomiphene12.5 mgOnce dailyTake in AM with food
13–16Tongkat Ali400 mgOnce dailyContinue (Foundation ongoing)
13–16Ashwagandha600 mgOnce dailyContinue (Foundation ongoing)
13–16NAC600 mgOnce dailyContinue (Foundation ongoing)
  • Avoid SSRIs, MAOIs, or CYP2D6 inhibitors during this SERM window (risk of PK interactions).
  • Be alert for vision disturbances (rare, but known SERM risk).
  • Abstain from heavy alcohol and check hormone & liver panels 2–4 weeks after finishing Mini-PCT.

Compounds in this stack

13 linked · tap for full guide

Berberine

AMPK Activator / Isoquinoline Alkaloid

Supplementt½ Several hours (parent); active metabolites detectable 24–48hOral

N-Acetylcysteine

Glutathione Precursor / Antioxidant

Supplementt½ 5–6 hoursOral

TUDCA

Hepatoprotective Bile Acid

Supplementt½ 1–2 hours (plasma); functional duration ~8–12 hours via enterohepatic recyclingOral

Fadogia Agrestis

Natural Testosterone Support Herb

Supplementt½ Unknown (no human PK data)Oral

Tongkat Ali

Steroidogenic Botanical

Supplementt½ 1–2 hours (eurycomanone)Oral

Ashwagandha

Adaptogen / HPA-axis Modulator

Supplementt½ 7–10 hours (withanolides, extrapolated)Oral

Creatine Monohydrate

Ergogenic Amino Acid Derivative

Supplementt½ ~1–1.5 hours (plasma); muscle saturation persists for weeksOral

Enclomiphene Citrate

SERM (HPTA Stimulator)

Ancillary / PCTt½ ~10 hoursOralResearch

AC-262536

Partial Agonist SARM

SARMt½ ~10–24 hours (inferred, not formally characterized in humans)OralPCTResearch

Retatrutide

GLP-1 / GIP / Glucagon Triple Agonist

Metabolic Peptidet½ ~6 daysSubQResearch

MK-677

Growth Hormone Secretagogue (GHS-R1a Agonist)

GH & IGFt½ 4–6 hoursOralResearch

TB-500

Actin-Sequestering Peptide

Healing Peptidet½ 2–3 hours (plasma); tissue effects persist far longerSubQResearch

BPC-157

Cytoprotective Peptide

Healing Peptidet½ Under 30 minutes (plasma); downstream effects persist well beyond clearanceSubQResearch

How they work together

Combined effectiveness
Average 0–10 score per dimension across the compounds in this stack (simple mean per axis).
Pairwise synergies

Multipliers applied to the projection above when these compounds run together. Values > 1 indicate a bonus, < 1 a penalty.

PairTypeLeanFat lossRecovery
MK-677+Creatine Monohydrate
additive×1.04×1.00×1.05
MK-677+BPC-157
synergistic×1.12×1.00×1.22
Retatrutide+BPC-157
synergistic×1.10×1.08×1.22
TUDCA+N-Acetylcysteine
synergistic×1.00×1.00×1.18
BPC-157+TB-500
synergistic×1.08×1.00×1.25
Retatrutide+Creatine Monohydrate
synergistic×1.13×1.09×1.07
Ashwagandha+Fadogia Agrestis
synergistic×1.15×1.05×1.18
Ashwagandha+Tongkat Ali
synergistic×1.12×1.10×1.20
Tongkat Ali+Fadogia Agrestis
synergistic×1.15×1.05×1.12
MK-677+Berberine
additive×1.00×1.07×1.00
AC-262536+Enclomiphene Citrate
synergistic×1.12×1.08×1.18
AC-262536+TB-500
synergistic×1.13×1.02×1.22
AC-262536+MK-677
synergistic×1.17×1.04×1.18
AC-262536+BPC-157
synergistic×1.14×1.08×1.28
AC-262536+TUDCA
synergistic×1.08×1.00×1.12

Cycle outcome projection

Projection across all phases (16 weeks total) using the same math as the stack-calculator tool. Adjust gender, cycle length, and goal to see how the numbers move.

Projected Outcomes
Male · 16-week cycle · Berberine + N-Acetylcysteine + TUDCA + Fadogia Agrestis + Tongkat Ali + Ashwagandha + Creatine Monohydrate + Enclomiphene Citrate + AC-262536 + Retatrutide + MK-677 + TB-500 + BPC-157
16wk

Body Transformation Preview

Very Lean(-15 lb)
Very LeanAverageHigh BF
Muscular
UntrainedAthleticEnhanced
Before: Muscular, Very Lean body fat
BeforeMuscular · Very Lean BF
After Cycle: Enhanced, Very Lean body fat
After CycleEnhanced · Very Lean BF
+65.8 lb muscle−31.9 lb fatover 16 weeks

Lean Mass Gain

65.8 lbs

49.4–82.3 lbs range

Fat Loss

31.9 lbs

23.9–39.9 lbs range

Lean Synergy Bonus

+322%

from compound pairing

Fat Loss Synergy

+89%

from compound pairing

Per-Compound Contribution

Berberine−0.10 lb fat/wk
N-AcetylcysteineRecovery / other
TUDCARecovery / other
Fadogia AgrestisRecovery / other
Tongkat AliRecovery / other
Ashwagandha+0.15 lb lean/wk
Creatine Monohydrate+0.15 lb lean/wk
Enclomiphene CitrateRecovery / other
AC-262536+0.60 lb lean/wk
Retatrutide−1.20 lb fat/wk
MK-677+0.30 lb lean/wk
TB-500Recovery / other
BPC-157Recovery / other

Fat Loss by Week

Wk 1
2.46 lb
Wk 2
2.39 lb
Wk 3
2.32 lb
Wk 4
2.26 lb
Wk 5
2.20 lb
Wk 6
2.14 lb
Wk 7
2.08 lb
Wk 8
2.02 lb
Wk 9
1.96 lb
Wk 10
1.90 lb
Wk 11
1.84 lb
Wk 12
1.79 lb
Wk 13
1.73 lb
Wk 14
1.67 lb
Wk 15
1.61 lb
Wk 16
1.56 lb

Where to buy

grouped by vendor · fewest checkouts first

NextChems

NextChems

5 of 13 items
Ships from USCapsules & solutions available

Affiliate link — we may earn a commission at no cost to you.

10% off — auto-applied at checkout

Cycle support also at NextChems

Not at NextChems: Berberine, N-Acetylcysteine, TUDCA, Fadogia Agrestis, Tongkat Ali, Ashwagandha, Creatine Monohydrate, TB-500 — source elsewhere.

Swiss Chems

Swiss Chems

5 of 13 items
Ships from USWidest catalogCapsules, powders & injectables

Affiliate link — we may earn a commission at no cost to you.

10% off — auto-applied at checkout

Cycle support also at Swiss Chems

Not at Swiss Chems: Berberine, N-Acetylcysteine, TUDCA, Fadogia Agrestis, Tongkat Ali, Ashwagandha, Creatine Monohydrate, Retatrutide — source elsewhere.

Real Peptides

Real Peptides

Our pick4 of 13 items
Ships from USLogin RequiredPeptide specialistVials, capsules & sprays

Affiliate link — we may earn a commission at no cost to you.

20% off — auto-applied at checkout

Cycle support also at Real Peptides

Not at Real Peptides: Berberine, N-Acetylcysteine, TUDCA, Fadogia Agrestis, Tongkat Ali, Ashwagandha, Creatine Monohydrate, Enclomiphene Citrate, AC-262536 — source elsewhere.

Source separately
Items in this stack that none of the vendors above carry.

Conclusion

This is the most complete, natty-plus protocol for anyone chasing maximum recomp and aesthetics without crossing the SARM/AAS suppression line. You retain your HPTA, add muscle, accelerate fat loss and recovery, and end with a platform for either cruising or launching a more aggressive cycle. Treat this as both a destination and a perfect launchpad for bigger moves. Once you've finished, reassess, run a full blood panel, and move upward or maintain as your goals dictate.

Project cycle outcomesOpen in stack builder← All stacks

Updated 2026-04-19