Comparison

LGD-2226 vs LGD-4033

Old-school quinolinone SARM for bone vs. flagship lean-mass gainer.

LGD-2226

Nonsteroidal Selective Androgen Receptor Modulator

SARMt½ Not formally published; once-daily oral dosing supported in preclinical models

LGD-4033

Selective Androgen Receptor Modulator

SARMt½ 24–36 hours

Effectiveness Profile

LGD-2226
LGD-4033

At a Glance

 LGD-2226LGD-4033
TypeSARMSARM
Legal statusResearchResearch
Half-lifeNot formally published; once-daily oral dosing supported in preclinical models24–36 hours
Preferred routeOralOral
Dose frequencyonce-dailyonce-daily
Beginner dose2.5–5 mg5–5 mg
Intermediate dose5–10 mg5–10 mg
Advanced dose10–15 mg10–20 mg
Cycle length6–12 wks6–8 wks
Bioavailability—90%
Time to peak2h2h
Active duration24h24h
StorageRoom temperature, sealed, protected from light and moistureRoom temperature, dry, away from light
PCT requiredYesYes
Ancillaries requiredYesYes
Safe for womenNoNo
Anabolic / androgenic200 / 50500 / 1

Verdict

LGD-2226 wins for low androgenic sides, minimal prostate impact, and theoretical long-term bone gains without libido suppression (per rodent data).

LGD-4033 wins for clinical-grade lean mass accrual, larger human dataset, easy sourcing, and predictable results in strength, recomp, or cutting protocols. If raw anabolism, reliability, or community integration is the metric, LGD-4033 is the clear leader.

Pick A or B?

Pick LGD-2226 if:

  • Targeting bone strength/density as a primary endpoint
  • Prioritizing low androgenic and estrogenic activity (e.g., sensitive to prostate or scalp issues)
  • Interested in experimental SARMs or completing a SARM portfolio
  • Chasing libido preservation (per rodent models)
  • Stacking with MK-677 or GH-axis peptides for joint or bone benefits

Pick LGD-4033 if:

  • Lean mass and strength increase are main goals
  • Want a SARM with a robust, well-documented cycle structure and side effect profile
  • Interested in proven 8-week bulking or recomp runs
  • Prioritize reliable sourcing and compound purity
  • Looking for support and shared experience in the community for troubleshooting protocols

PCT & Ancillaries

Research protocols built around LGD-2226 and LGD-4033 typically pair them with PCT and ancillary compounds — these are the ones our partners carry.

Real Peptides

Real Peptides

Our pick
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