Shredded Stack
Risk: Moderate-HighMaximum fat loss while preserving lean muscle. Designed for a cut phase with aggressive caloric deficit.
Overview
The Shredded Stack combines a triple-agonist GLP-1/GIP/glucagon (Retatrutide) for appetite suppression and metabolic drive, MOTS-c for mitochondrial fat oxidation, AC-262 to preserve (and potentially build) lean muscle in a deficit, and Enclomiphene to maintain natural testosterone during suppression.
This is not a beginner stack. Each component carries meaningful risk and requires careful monitoring.
Why this stack works
Retatrutide: Triple agonist (GLP-1 / GIP / glucagon) — the most aggressive metabolic driver currently available. Drives the caloric deficit through appetite suppression, satiety, and elevated energy expenditure.
MOTS-c: Mitochondrial-derived peptide that improves insulin sensitivity and fat oxidation. Pairs well with a GLP-1 by improving metabolic flexibility under deficit-induced stress.
AC-262: Non-steroidal SARM with a clean lean-mass preservation profile. In a deficit, its primary function is muscle preservation. Suppressive — hence the Enclomiphene.
Enclomiphene: Selective estrogen receptor modulator that maintains LH/FSH signalling, preventing testosterone from cratering during AC-262 suppression.
Protocol timeline
2 phases · 16 weeks total
Timeline shows the 16-week cycle. Bars overlap when phases run concurrently. Click a bar to jump to its detail card.
The interactive timeline loads here. Phase details are available below.
| Week | Compound | Dose | Frequency | Notes |
|---|---|---|---|---|
| 1–2 | Retatrutide | 2mg | Weekly SubQ | Titration phase |
| 3–4 | Retatrutide | 4mg | Weekly SubQ | — |
| 5–12 | Retatrutide | 6–8mg | Weekly SubQ | Maintenance |
| 1–12 | MOTS-c | 10mg | 2× weekly SubQ | Mitochondrial support — fat oxidation |
| 3–12 | AC-262 | 15–25mg | Daily Oral | Lean-mass preservation in a deficit |
| 1–12 | Enclomiphene | 12.5–25mg | Daily Oral | Maintain endogenous testosterone |
Items needed for this phase
- Enclomiphene— Rx-grade preferred — supports HPTA during AC-262 suppression
Ancillaries throughout the cut:
- AC-262 is suppressive — Enclomiphene + the PCT phase below cover recovery
- Retatrutide: titrate slowly to avoid GI side effects
- Liver support (TUDCA 250mg/day or NAC 600mg/day throughout)
- Consider on-cycle testosterone support if libido drops
Week 13–16: Nolvadex (Tamoxifen) 40/20/20/20mg/day or Clomid 50/25/25mg/day. Continue until bloodwork confirms HPTA recovery.
Items needed for this phase
- Nolvadex (Tamoxifen)— Rx required — primary SERM for PCT
- Clomid (Clomiphene)— Alternative SERM if Nolvadex is unavailable
Where to buy
grouped by vendor · fewest checkouts first
- EnclomipheneCut— Rx-grade preferred — supports HPTA during AC-262 suppression
- Nolvadex (Tamoxifen)PCT— Rx required — primary SERM for PCT
- Clomid (Clomiphene)PCT— Alternative SERM if Nolvadex is unavailable
Conclusion
The Shredded Stack delivers, but it demands respect. If you're running this, you should have bloodwork before, mid-cycle, and post-PCT. Know what you're doing. Don't skip the PCT.