Comparison
S-23 vs YK-11
S-23: maxed-out suppression and hardening. YK-11: unique myostatin modulation with steroidal risks.
S-23
Aryl-Propionamide SARM (Full AR Agonist)
YK-11
Steroidal SARM / Follistatin Inducer
Effectiveness Profile
At a Glance
| S-23 | YK-11 | |
|---|---|---|
| Type | SARM | SARM |
| Legal status | Research | Research |
| Half-life | ~11–12 hours (rat PK; not formally characterized in humans) | ~6–10 hours (estimated) |
| Preferred route | Oral | Oral |
| Dose frequency | twice-daily | twice-daily |
| Beginner dose | 10–15 mg | 5–7.5 mg |
| Intermediate dose | 15–20 mg | 8–10 mg |
| Advanced dose | 20–30 mg | 10–15 mg |
| Cycle length | 6–10 wks | 6–8 wks |
| Bioavailability | 96% | — |
| Time to peak | 2h | 1.5h |
| Active duration | 24h | 10h |
| Storage | Room temperature, dry, out of direct light; refrigerate liquid solutions for long-term storage | Room temperature, dry, away from light |
| PCT required | Yes | Yes |
| Ancillaries required | Yes | Yes |
| Safe for women | No | No |
Verdict
S-23 wins for raw androgen receptor potency, visual hardening, zero estrogen/water retention, and predictable results when run for late-stage cutting or contest prep. Sourcing is easier and it's better characterized in the community, with more predictable shutdown/manageable PCT.
YK-11 wins for unique mechanism: myostatin inhibition via follistatin upregulation that offers legitimate recomposition potential. It's the only SARM-like designer that targets both AR and myostatin. For advanced users seeking a truly different pathway, it's the standout; also, some find androgenic sides milder than S-23 per mg. But the sourcing risk (mislabeled/mispropped powder, underdosing) is much higher.
Pick A or B?
Pick S-23 if:
- You want maximal dryness and muscle definition for the last 6–8 weeks of a prep/cut.
- You need a SARM "finisher" with true androgenic hardness, but avoid injectable orals.
- Managing estrogen is a concern (no water retention or gyno risk on S-23).
- You want a compound with consistent results and a large user knowledge base.
- You're willing to commit to full PCT and understand the shutdown risk.
Pick YK-11 if:
- You're chasing additional lean mass via myostatin inhibition (follistatin upregulation) and want something outside classic SARMs.
- You want a recomp or aesthetic lean-gains compound to layer with low-test/masteron or other SARMs.
- You're experienced with PCT and comfortable managing more steroid-like lipid/liver risks.
- Milder (per mg) androgenic effects are desirable, but you still want visible hardening/recomp.
- You're able to source real YK-11 from a vendor who provides COA testing — no exceptions.
Where to Buy
Swiss Chems
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