Comparison
RAD-140 vs S-23
RAD-140 for clean anabolic mass, S-23 for hard, dry, competition-level finish.
RAD-140
Selective Androgen Receptor Modulator
S-23
Aryl-Propionamide SARM (Full AR Agonist)
Effectiveness Profile
At a Glance
| RAD-140 | S-23 | |
|---|---|---|
| Type | SARM | SARM |
| Legal status | Research | Research |
| Half-life | ~44 hours | ~11–12 hours (rat PK; not formally characterized in humans) |
| Preferred route | Oral | Oral |
| Dose frequency | once-daily | twice-daily |
| Beginner dose | 5–10 mg | 10–15 mg |
| Intermediate dose | 10–20 mg | 15–20 mg |
| Advanced dose | 20–30 mg | 20–30 mg |
| Cycle length | 6–12 wks | 6–10 wks |
| Bioavailability | 50% | 96% |
| Time to peak | 1.5h | 2h |
| Active duration | 48h | 24h |
| Storage | Room temperature, dry, away from light. Liquid suspensions stable for 12+ months. | Room temperature, dry, out of direct light; refrigerate liquid solutions for long-term storage |
| PCT required | Yes | Yes |
| Ancillaries required | Yes | Yes |
| Safe for women | No | No |
| Anabolic / androgenic | 90 / 1 | 500 / 95 |
Verdict
RAD-140 wins for moderate-to-high anabolic gains with a friendlier side-effect profile, especially for users chasing muscle growth without severe HPG axis shutdown or desiring a less androgenic choice for hair retention. Its half-life and manageable suppression make it the SARM of choice for first-timers and moderate cycles.
S-23 wins for raw AR binding potency, delivering the dry, hard, contest-prep look with maximal aggression and strength preservation in a deficit. Nothing else in the SARM category comes close for hardness—if you can handle the near-total suppression and want a true finishing agent, S-23 is unmatched.
Pick A or B?
Pick RAD-140 if:
- You want robust lean mass and strength gains with a lower risk of complete shutdown
- Hair retention is a high priority (finasteride-sensitive, avoiding DHT conversion)
- Running your first oral SARM cycle and want a baseline for tolerability
- Looking for a versatile SARM to stack (ostarine for recomp, cardarine for cut, MK-677 for bulk)
- Want meaningful results in an 8-week cycle with moderate PCT
Pick S-23 if:
- You need maximum hardness, dryness, and visible muscle separation for a peak phase or photoshoot
- You're advanced and already understand/recover well from harsh HPG suppression
- Stacking with a test base and want a "hardener" alongside injectable AAS
- You want a short-cycle contest prep finisher where strength and aggression need to be at their peak
- You can tightly manage side effects, PCT, and regression risk post-cycle
Where to Buy
Swiss Chems
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- RAD-140· Buy RAD-140 (Testolone), (10mg/capsule) 60 Capsules - SwissChems - Buy Best Quality Peptides, SARMS OnlineBuy RAD-140
- S-23· Buy S-23 (10mg/capsule), 60 Capsules - SwissChems - Buy Best Quality Peptides, SARMS OnlineBuy S-23

NextChems
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- RAD-140· Testolone (RAD-140), 10mg - 60 capsules - Next ChemsBuy RAD-140
- RAD-140· RAD140 Solution, 20mg/ML - 50ML - Next ChemsBuy RAD-140
- S-23· S-23, 10 mg - 60 capsules - Next ChemsBuy S-23