Comparison
Human Chorionic Gonadotropin vs HMG (Human Menopausal Gonadotropin)
hCG maintains testicular function on cycle; HMG restores fertility via FSH support.
Human Chorionic Gonadotropin
LH Analog / Gonadotropin
HMG (Human Menopausal Gonadotropin)
Gonadotropin (FSH + LH)
Effectiveness Profile
At a Glance
| Human Chorionic Gonadotropin | HMG (Human Menopausal Gonadotropin) | |
|---|---|---|
| Type | Ancillary / PCT | Ancillary / PCT |
| Legal status | Rx-Only | Rx-Only |
| Half-life | Biphasic — initial ~6h, terminal ~33h | FSH ~24 h; LH ~10–12 h |
| Preferred route | SubQ | SubQ |
| Dose frequency | twice-weekly | three-times-weekly |
| Beginner dose | 250–500 IU | 75–75 IU |
| Intermediate dose | 500–1500 IU | 75–150 IU |
| Advanced dose | 1500–3000 IU | 150–300 IU |
| Cycle length | 2–52 wks | 12–24 wks |
| Bioavailability | 100% | 70% |
| Time to peak | 16h | 9h |
| Active duration | 96h | 48h |
| Storage | Lyophilized: room temp stable. Reconstituted: 2–8°C refrigerated, ~30 days (up to 60 if kept cold and stable). | Lyophilized vial stored at 2–8°C (or room temp per label); reconstituted solution used immediately or refrigerated short-term |
| PCT required | No | No |
| Ancillaries required | Yes | Yes |
| Safe for women | No | Yes |
Verdict
Human Chorionic Gonadotropin wins for: On-cycle testicular maintenance, simple PCT kickstarts, rapid bump in intratesticular testosterone, ease of dosing, and lower cost/greater availability. Ideal when LH mimicry alone is sufficient to preserve testicular health and testosterone output.
HMG (Human Menopausal Gonadotropin) wins for: Full-spectrum fertility restoration—especially where spermatogenesis is suppressed after long cycles—as it delivers both FSH (via urinary-derived FSH/LH) and LH activity. HMG is the gold standard for bringing sperm count back up in cases where hCG alone isn't sufficient. Essential for users with FSH-flatlined HPTA or those planning conception after heavy suppression.
Pick A or B?
Pick Human Chorionic Gonadotropin if:
- You want to maintain testicular size and function while on TRT, cruising, or blasting.
- Your primary goal is to keep endogenous testosterone and avoid atrophy during suppression.
- You want a simple PCT kickstart before a SERM run.
- You're not actively trying to conceive but want to maintain fertility reserves.
- Cost, convenience, and fewer injections matter to you.
Pick HMG (Human Menopausal Gonadotropin) if:
- You're actively trying to restore or maximize fertility (spermatogenesis) after long-term suppression.
- Previous hCG-only protocols haven't brought your sperm count back up.
- You're running fertility labs and see flatlined FSH despite normal testicular volume.
- You're stacking with hCG for a full mimetic of pituitary output (LH+FSH).
- Refractory cases or IVF prep with a timeline for conception.
Where to Buy
Swiss Chems
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