Comparison
GW-0742 vs Stenabolic
GW-0742: ultra-potent PPARδ agonist. Stenabolic: metabolic modulator with a shorter half-life and softer effect.
GW-0742
PPARδ Agonist
Stenabolic
REV-ERB Agonist
Effectiveness Profile
At a Glance
| GW-0742 | Stenabolic | |
|---|---|---|
| Type | Other | Other |
| Legal status | Research | Research |
| Half-life | ~20–24 hours (extrapolated from GW-501516; no human PK published) | 2–4 hours (rodent data; no validated human PK) |
| Preferred route | Oral | Oral |
| Dose frequency | once-daily | three-times-daily |
| Beginner dose | 4–7 mg | 10–20 mg |
| Intermediate dose | 8–10 mg | 20–30 mg |
| Advanced dose | 10–15 mg | 30–40 mg |
| Cycle length | 6–12 wks | 6–12 wks |
| Bioavailability | — | 2% |
| Time to peak | 5h | 1h |
| Active duration | 24h | 4h |
| Storage | Room temperature, sealed and away from light; refrigerate reconstituted oral solutions | Room temperature, protected from light; refrigerate liquid preparations |
| PCT required | No | No |
| Ancillaries required | No | No |
| Safe for women | Yes | Yes |
Verdict
GW-0742 wins for: Potency in endurance/recomp applications, clean once-daily administration thanks to longer half-life, direct lipid support during oral-heavy cycles, and a receptor mechanism with heavy study behind it. It delivers a noticeably stronger conditioning effect per milligram versus either cardarine or Stenabolic, with more robust lipid improvements and easier stacking protocols.
Stenabolic wins for: Soft metabolic enhancement with essentially zero androgenic or hormonal signature, extremely low toxicity, and lack of the specific tumorigenicity signal seen in PPARδ agonists. It's the safer pick for long cycles or stacking in women's or low-dose settings, and can be dosed around the clock for a mild but reliable energy and fat-oxidation bump—at the cost of inconvenient 3–4×/day scheduling due to short half-life.
Pick A or B?
Pick GW-0742 if:
- Maximum endurance and conditioning boost are top priority—serious cardio, HIIT, or cutting phases
- A cut or recomp protocol needs aggressive fat oxidation without hormone suppression
- Lipid support during strong oral AAS cycles is required (HDL drop mitigation)
- Sourcing isn't an issue and short, potent cycles (6–8 weeks) fit the plan
- Schedules favor once-daily administration for compliance
Pick Stenabolic if:
- Safety profile is top priority, and cycle length will stretch beyond 8 weeks
- Soft body recomp and metabolic effect is sufficient (cardio is supplementary, not primary driver)
- Ultra-low androgenic or hormonal footprint is needed (female, cruise, or sensitive users)
- Stacking with cardarine/GW compounds is planned and receptor overlap is to be avoided
- Willingness to dose 3–4× daily to work around short half-life isn't a blocker
Where to Buy

NextChems
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